Cannabis -vs- Hyptertension

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470879: CBD was well tolerated, and there were no adverse events on the day of stress tests. None of the subjects reported any adverse events over the following week.

Our data show that a single dose of CBD reduces resting blood pressure and the blood pressure response to stress, particularly cold stress, and especially in the post-test periods. This may reflect the anxiolytic and analgesic effects of CBD, as well as any potential direct cardiovascular effects. CBD also affected cardiac parameters but without affecting cardiac output. Giving the increasing use of CBD as a medicinal product, these hemodynamic changes should be considered for people taking CBD. Further research is also required to establish whether CBD has any role in the treatment of cardiovascular disorders such as a hypertension.


https://www.ncbi.nlm.nih.gov/pubmed/15451779:  We conclude that endocannabinoids tonically suppress cardiac contractility in hypertension and that enhancing the CB1-mediated cardiodepressor and vasodilator effects of endogenous anandamide by blocking its hydrolysis can normalize blood pressure. Targeting the endocannabinoid system offers novel therapeutic strategies in the treatment of hypertension.


http://www.ncbi.nlm.nih.gov/pubmed/17890433:  In animals, CBD reduced infarct size and reduced inflammation follow a heart attack.  Cannabidiol, a nonpsychoactive cannabis constituent, protects against myocardial ischemic reperfusion injury.


http://www.ncbi.nlm.nih.gov/pubmed/19900555:  CBD reduced acute and apoptotic brain damage when administered shortly after an ischemic brain event in mice.  The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors.


http://www.ncbi.nlm.nih.gov/pubmed/25492113: Cannabinoids administered to humans shortly after a stroke reduced infarct volume and improved brain functional outcome. Cannabinoids in experimental stroke: a systematic review and meta-analysis.






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